Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Moderately Good
Based on 70 Reviews
7.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Selenium (elemental) (from 20 mg L-Selenomethionine)
100 mcg
182%
Top Medical Research Studies
9
Selenium nanoparticles support heart health
We explored how selenium nanoparticles (SeNPs) could help reduce damage from heart attacks, specifically ischemia/reperfusion injury (I/RI). Using a method to create these nanoparticles, we found they possess remarkable properties that combat oxidative stress and inflammation.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
Read More
8
We explored the use of selenium-loaded porous silica nanospheres (Se@PSN) as a promising treatment for myocardial infarction (MI). This innovative approach targets harmful reactive oxygen species (ROS), which damage heart cells. By improving antioxidant activity and supporting mitochondrial function, Se@PSN help reduce heart tissue damage and maintain cardiac function after a heart attack. The findings suggest that Se@PSN could be a significant advancement for MI treatments and may offer hope in the clinical realm.
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9.5
We looked into how dietary selenium and zinc affect the risk of dilated cardiomyopathy (DCMP) in children. In this case-control study, 36 patients with DCMP were compared to 72 healthy children, assessing their dietary intakes using a food frequency questionnaire.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Read More
Most Useful Reviews
7.5
Improves heart health
185 people found this helpful
Selenium is an essential trace element that aids the body in combating oxidative damage, maintaining normal thyroid and immune functions, and enhancing heart and brain health. It also supports healthy cell division. I take it as prescribed by my doctor, and I am very pleased with the results.
Read More
9
Strengthens immune system
147 people found this helpful
I accept it with seaweed! This element plays an important role in metabolism and thyroid function, protecting cells from damage linked to oxidative stress. Selenium is crucial for bolstering the immune system, enhancing brain function, and reducing the risk of heart disease! I consume it with the Kelp supplement (dried iodine-containing algae). Please put YES if the review was helpful.
Read More
7.5
Lowers blood pressure
1021 people found this helpful
Selenium improves your hair and skin conditions. It reduces the risk of heart attacks, lowers blood pressure, boosts immunity, and stimulates metabolic processes. It's advisable to take selenium with vitamin E, as it enhances absorption. I take one tablet daily; give it a try!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
- All Researches
9.5
We looked into how dietary selenium and zinc affect the risk of dilated cardiomyopathy (DCMP) in children. In this case-control study, 36 patients with DCMP were compared to 72 healthy children, assessing their dietary intakes using a food frequency questionnaire.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Read More
9
Selenium nanoparticles support heart health
We explored how selenium nanoparticles (SeNPs) could help reduce damage from heart attacks, specifically ischemia/reperfusion injury (I/RI). Using a method to create these nanoparticles, we found they possess remarkable properties that combat oxidative stress and inflammation.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
Read More
9
We explored how a high selenium diet impacts heart health, especially under stress conditions like systolic overload. Using male mice, we compared those on a high selenium diet with those on a normal diet.
While high selenium didn’t change heart function under normal conditions, it significantly protected against heart issues caused by overload, reducing inflammation and heart muscle growth.
This suggests that a high selenium diet can be beneficial in combating certain heart problems, providing a proactive step for heart health.
While high selenium didn’t change heart function under normal conditions, it significantly protected against heart issues caused by overload, reducing inflammation and heart muscle growth.
This suggests that a high selenium diet can be beneficial in combating certain heart problems, providing a proactive step for heart health.
Read More
9
Selenium compound shows heart protection
We investigated the effects of a new selenium-containing compound, Se-SAHA, on heart failure caused by isoproterenol. Our study found that Se-SAHA helped protect heart cells from damage, reducing cardiac hypertrophy and fibrosis in lab models.
It effectively lowered harmful reactive oxygen species and increased vital antioxidative enzymes. Additionally, Se-SAHA hindered the buildup of autophagosomes and reversed certain harmful protein expressions linked to heart stress. Overall, these findings suggest that Se-SAHA could play a protective role in heart health by reducing oxidative stress and altering autophagic processes.
It effectively lowered harmful reactive oxygen species and increased vital antioxidative enzymes. Additionally, Se-SAHA hindered the buildup of autophagosomes and reversed certain harmful protein expressions linked to heart stress. Overall, these findings suggest that Se-SAHA could play a protective role in heart health by reducing oxidative stress and altering autophagic processes.
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9
We investigated the use of a new selenium delivery system to combat radiation-induced heart disease, which is a serious concern for cancer patients undergoing thoracic radiation. Our innovative oral microcarriers showed remarkable effects in protecting heart cells from radiation damage by reducing harmful reactive oxygen species.
Not only did this method improve heart function and reduce signs of damage, but it also supported the immune system by increasing beneficial immune cells after radiation exposure. These promising results suggest that selenium could play a key role in helping to manage and prevent heart complications from radiation therapy.
Not only did this method improve heart function and reduce signs of damage, but it also supported the immune system by increasing beneficial immune cells after radiation exposure. These promising results suggest that selenium could play a key role in helping to manage and prevent heart complications from radiation therapy.
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User Reviews
USERS' SCORE
Moderately Good
Based on 70 Reviews
7.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improves heart health
185 people found this helpful
Selenium is an essential trace element that aids the body in combating oxidative damage, maintaining normal thyroid and immune functions, and enhancing heart and brain health. It also supports healthy cell division. I take it as prescribed by my doctor, and I am very pleased with the results.
Read More
9
Strengthens immune system
147 people found this helpful
I accept it with seaweed! This element plays an important role in metabolism and thyroid function, protecting cells from damage linked to oxidative stress. Selenium is crucial for bolstering the immune system, enhancing brain function, and reducing the risk of heart disease! I consume it with the Kelp supplement (dried iodine-containing algae). Please put YES if the review was helpful.
Read More
7.5
Lowers blood pressure
1021 people found this helpful
Selenium improves your hair and skin conditions. It reduces the risk of heart attacks, lowers blood pressure, boosts immunity, and stimulates metabolic processes. It's advisable to take selenium with vitamin E, as it enhances absorption. I take one tablet daily; give it a try!
Read More
9
Stimulates immunity
14 people found this helpful
Selenium - the miracle element! This essential microelement influences bodily functions, participating in development and ageing, crucially affecting lifespan. Selenium acts as a powerful antioxidant, stimulates antibody production, and bolsters immune response. It normalises cell growth, combats cancer, and speeds healing after myocardial infarction. Many people lack this element, hence I continuously take it for immunity.
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9
Balances hormones
10 people found this helpful
I found that combining selenium with my thyroid medication effectively balances my hormone levels and has resulted in steady weight reduction. After two months I've reduced my thyroxine dosage successfully, integrating selenium and zinc which both support my heart health.
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Frequently Asked Questions
9
Balances hormones
10 people found this helpful
I found that combining selenium with my thyroid medication effectively balances my hormone levels and has resulted in steady weight reduction. After two months I've reduced my thyroxine dosage successfully, integrating selenium and zinc which both support my heart health.
6
Improves hair health
68 people found this helpful
Thank you, iHerb! Your reviews have helped me restore my long-standing alopecia. After two months using a mix including Selenium, I see results! My hair is stronger, more elastic, and new hairs are emerging in areas where they hadn’t grown in years. I’ve also noticed concrete improvements in my health, indicating that the treatments are effective. Selenium is crucial for immune response and detoxification, affecting vital organs like the heart. Do not give up!
7.5
Heart function improvement
4 people found this helpful
On a doctor's recommendation, selenium is prescribed for heart disease prevention. A deficiency can adversely affect heart function. It aids the heart's performance and reduces inflammation, helping prevent blood clots and serious complications.
7.5
Lowers blood pressure
1021 people found this helpful
Selenium improves your hair and skin conditions. It reduces the risk of heart attacks, lowers blood pressure, boosts immunity, and stimulates metabolic processes. It's advisable to take selenium with vitamin E, as it enhances absorption. I take one tablet daily; give it a try!
7.5
Boosted energy levels
1 people found this helpful
Taking selenium has been vital for my health, energising my body and improving immunity. I used it for latent anaemia, which led to constant lip seizures despite taking various vitamin supplements. After incorporating selenium into my routine, the seizures ceased. Although I did not test my selenium levels, my overall health has significantly improved, allowing me to get up in the mornings with more energy and vitality.
9
Heart improvement noted
6 people found this helpful
Very Working Selenium, taken with Kelp NOW 325mcg, enhances thyroid function and swiftly addresses hypothyroidism. It strengthens my heart and memory, effectively restoring the heart post-heart attack and the brain post-stroke, whilst also reducing the risk of such occurrences.
9
Reduces cancer risk
9 people found this helpful
Selenium is beneficial as it lowers the likelihood of oncological diseases. It protects cells from DNA damage, assists in normal cell growth, and helps restore damaged cells. It participates in thyroid hormone production, normalises the endocrine system, and strengthens the immune system. Selenium protects against cardiovascular ailments and enhances reproductive function in both men and women.
9
Strengthens immune system
147 people found this helpful
I accept it with seaweed! This element plays an important role in metabolism and thyroid function, protecting cells from damage linked to oxidative stress. Selenium is crucial for bolstering the immune system, enhancing brain function, and reducing the risk of heart disease! I consume it with the Kelp supplement (dried iodine-containing algae). Please put YES if the review was helpful.
9
Quality of life
2 people found this helpful
An essential supplement for quality life. Selenium plays a crucial role in the immune system, preventing ageing, and is a strong antioxidant. It strengthens blood vessels, safeguards the heart against damage, and normalises the immune system. For effective results, an adult should take 200 mg per day.
8
We examined the potential of selenium-quantum-dot-loaded silica nanoparticles (Se@PSN) to treat myocardial ischemia-reperfusion (IR) injury, which is often exacerbated by ferroptosis and mitochondrial dysfunction.
Our study demonstrated that Se@PSN significantly improved mitochondrial function and reduced oxidative stress in cardiac cells. These nanoparticles effectively lowered ferroptosis levels and showed great biocompatibility.
Overall, while Se@PSN showed promise in treating myocardial IR injury, further research is needed to solidify its clinical applications.
Our study demonstrated that Se@PSN significantly improved mitochondrial function and reduced oxidative stress in cardiac cells. These nanoparticles effectively lowered ferroptosis levels and showed great biocompatibility.
Overall, while Se@PSN showed promise in treating myocardial IR injury, further research is needed to solidify its clinical applications.
9
We explored how a high selenium diet impacts heart health, especially under stress conditions like systolic overload. Using male mice, we compared those on a high selenium diet with those on a normal diet.
While high selenium didn’t change heart function under normal conditions, it significantly protected against heart issues caused by overload, reducing inflammation and heart muscle growth.
This suggests that a high selenium diet can be beneficial in combating certain heart problems, providing a proactive step for heart health.
While high selenium didn’t change heart function under normal conditions, it significantly protected against heart issues caused by overload, reducing inflammation and heart muscle growth.
This suggests that a high selenium diet can be beneficial in combating certain heart problems, providing a proactive step for heart health.
7
Environmental metals and heart risk
We examined the impact of environmental metallic and metalloid pollutants, such as arsenic and lead, on heart disease and overall mortality by reviewing existing meta-analyses and systematic reviews. Our search included databases like PubMed and Web of Science, identifying various health outcomes associated with these contaminants.
Worryingly, exposure to harmful metals correlated with increased cardiovascular events. However, we found promising indications that zinc and selenium might provide some protective benefits against heart disease and mortality. While the evidence varied in quality, the protective potential of selenium remains a positive takeaway.
Worryingly, exposure to harmful metals correlated with increased cardiovascular events. However, we found promising indications that zinc and selenium might provide some protective benefits against heart disease and mortality. While the evidence varied in quality, the protective potential of selenium remains a positive takeaway.
References
- Li T, Liu X, Yang B, Wang Z, Chen Y, et al. Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy. Free Radic Biol Med. 2025;232:292. doi:10.1016/j.freeradbiomed.2025.03.004
- He X, Sun H, Zhao Y, Fu X, Wang M, et al. Association of environmental metallic and metalloid contaminants with cardiovascular and all-cause mortality: An umbrella review of systematic reviews and meta-analyses. Eur J Prev Cardiol. 2025. doi:10.1093/eurjpc/zwaf118
- Li T, Yang B, Liu X, Shi D, Wang Z, et al. Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction. Int J Nanomedicine. 2025;20:1843. doi:10.2147/IJN.S500810
- Chen C, Ma J, Duan S, Xue M, Yang Z, et al. Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation. Biomaterials. 2025;318:123119. doi:10.1016/j.biomaterials.2025.123119
- Chen Q, Wang WY, Xu QY, Dai YF, Zhu XY, et al. The enhancing effects of selenomethionine on harmine in attenuating pathological cardiac hypertrophy via glycolysis metabolism. J Cell Mol Med. 2024;28:e70124. doi:10.1111/jcmm.70124
- Heuer RM, Falagan-Lotsch P, Okutsu J, Deperalto M, Koop RR, et al. Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio). Cardiovasc Toxicol. 2024;24:1287. doi:10.1007/s12012-024-09910-0
- Bhattarai U, Xu R, He X, Pan L, Niu Z, et al. High selenium diet attenuates pressure overload-induced cardiopulmonary oxidative stress, inflammation, and heart failure. Redox Biol. 2024;76:103325. doi:10.1016/j.redox.2024.103325
- Sun Y, Mao Q, Zhou D, Tian J, Du H, et al. Associations of multiple blood metals with cardiac structure and function: A cross-sectional study in a CAD population. Environ Pollut. 2024;360:124718. doi:10.1016/j.envpol.2024.124718
- Marhamati S, Younesian O, Mir SM, Hosseinzadeh S, Joshaghani HR, et al. The effects of high doses of selenium supplementation on mRNA and protein levels of cMLCK levels and total antioxidant capacity in rat heart tissue. Food Chem Toxicol. 2024;191:114886. doi:10.1016/j.fct.2024.114886
- Masle AM, Kibel A, Jukić I, Čičak P, Selthofer-Relatić K, et al. Enhancing Endothelial Function with Nutrient-Enriched Table Hen Eggs: A Randomized Study in Patients Recovering from Acute Coronary Syndrome. Clin Interv Aging. 2024;19:953. doi:10.2147/CIA.S461821
- Cheng T, Liu C, Wang Y, Li G, Feng L, et al. A novel histone deacetylase inhibitor Se-SAHA attenuates isoproterenol-induced heart failure via antioxidative stress and autophagy inhibition. Toxicol Appl Pharmacol. 2024;487:116957. doi:10.1016/j.taap.2024.116957
- Liu C, Wang W, Lai H, Chen Y, Li L, et al. Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease. Bioact Mater. 2024;37:393. doi:10.1016/j.bioactmat.2024.03.034
- Aryafar M, Mahdavi M, Shahzadi H, Ranjbar YR, Sohouli MH, et al. Association between dietary selenium and zinc intake and risk of dilated cardiomyopathy in children: a case-control study. BMC Pediatr. 2024;24:251. doi:10.1186/s12887-024-04706-1
- Karaye KM, Sa'idu H, Ishaq NA, Balarabe SA, Ahmed BG, et al. Selenium Deficiency as a Risk Factor for Peripartum Cardiomyopathy. West Afr J Med. 2024;41:209.
- Li SJ, Wang AW, Huang KL, Yang Y. Recent Advances on Selenium Nutrition and Keshan Disease. Int Heart J. 2024;65:173. doi:10.1536/ihj.23-628
- Al-Mubarak AA, Markousis Mavrogenis G, Guo X, De Bruyn M, Nath M, et al. Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes. Redox Biol. 2024;70:103046. doi:10.1016/j.redox.2024.103046
